Anatomy and Cell Biology 2221 Lecture Notes - Lecture 12: Serotonin Antagonist, Aplysia Gill And Siphon Withdrawal Reflex, Startle Response
27 Feb 2015
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Outlines the circuits of gill withdrawal reflex. Serotonergic synapses that synapse onto these neurons sensitize the gill withdrawal reflex. Pnc make pnc giant neurons more excitable so that when acoustic input comes it has a greater response. First startle response is the highest and then with 3-5 startle responses it declines to half the amplitude: short term habituation. Theory: any stimulus induces habituation but also induces sensitization at the same time. If we go back to startle response pathway habituation occurs after repeated stimuli but that stimulus also triggers a different pathway leading to sensitization (serotonin release: behavioral outcome that we measure is the sum of both. If you observe habituation habituation is stronger than sensitization and vice versa. How to design an experiment: hypothesis, compound a reduces blood sugar , gene xy affects cognitive function , test, measurement of blood sugar, memory test, subjects, 40 volunteers, 25-30 years of age if human, 40 male rats, 300g.
