BIOL 1013 Lecture Notes - Amygdala, Ventral Tegmental Area, Antipsychotic
1 Feb 2013
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Synthesis: tyr dopa da via tyr-h and db h (see monoamines i) Da is directly transported into vesicles, released onto da receptors (5 types), and inactivated by reuptake (a target of cocaine) Evidence for da as a nxt: tyr-h+/db h- cells, distinct mechanism for da release/ reuptake/reception, parkinson"s dz has selective loss of da neurons. Synthesis: trp 5-oh-trp 5-ht (aka serotonin) via trp-h, aad. 5-ht is directly transported into vesicles, released onto 5-ht receptors (>14 types), and inactivated by reuptake. Serotonin is a nxt and also involved in vascular tone. Lsd is a mimic of 5-ht; prozac is a serotonin-specific reuptake inhibitor (ssri) Anatomical distribution of ne, 5-ht, da: widespread influences throughout brain. Ne cell bodies found in locus ceruleus and lateral tegmentum, projects into all parts of forebrain to set general tone (e. g. alertness, attention level) 5-ht cell bodies found in midbrain raphe, also projects into all parts of forebrain to set general tone.
