5-350 Lecture Notes - Klinefelter Syndrome, Ovarian Follicle, Haploinsufficiency
28 Jan 2013
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Document Summary
Integrated with urinary system development relies upon mesonephric ducts (wolffian ducts) form vas deferens and epididymis in males closed system. Mullerian ducts - paramesonephric ducts that arise alongside mesonephric ducts derived from surface epithelium form oviducts/uterus of female. **embryos are identical until week 6 after this, genetic sex is expressed** Primordial germ cells arise very early in development, distinct from gonad position. Proliferate as they migrate to the gonadal ridge. Pin-1 (increase cell cycle rate inc. proliferation) Pgc"s are not required for testes, but are required for ovaries. Xy pgc"s in testes will have mitotic arrest until puberty. Xx pgc"s in testes will die after mitosis resumes at puberty. Xy pgc"s in ovaries will have meotic arrest until puberty. **xy pgc"s in ovaries may survive after meosis resumes** mitotic arrest meiotic arrest sry, tdf. Central dogma of sex development genetic sex gonadal sex phenotypic sex (no gonads phenotypically female)
