MICR 303 Lecture Notes - Lecture 2: Thoracic Duct, Neutrophil, Natural Killer Cell
13 Jan 2018
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Document Summary
Principles of adaptive immunity: defects in innate immunity: Low conc. of neutrophils -> highly susceptible to fungal and bacterial infection. Symptoms observed in mouth, throat, skin, lungs. Defect of the regulation of complement system. Excessive production of vasoactive mediators that cause in ammation ( uid accumulation in tissue -> extreme swelling) Innate includes: anatomic barriers, complement/antimicrobial proteins (c3, defensives, Reg3y), innate immune cells (macrophages, granulocytes, natural killer cells) Adaptive includes: b cells/antibodies, t cells an antigen -specific response comprising speci c immune cells. Immunity mediated by antibodies (humoral immunity, cell mediated) Includes proteins, glycoproteins, polysaccharides of pathogen but also chemical structures (metals -> nickel, drugs -> penicillin, organic materials) Diversity in antigen binding sites -> can deal with any foreign pathogen. Myst bind antigen to antigen receptor (acquire effector and memory activity) Encoded by antibody genes; membrane immunoglobulin (mlg) Looks like antibody, embedded in membrane of b cell.
