BIOC 300B Lecture Notes - Lecture 32: Phosphatidic Acid, Lipid Bilayer, Cerebroside
5 Apr 2018
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Bioc300b lecture 32: lipid structure common types of membrane lipids: Derived from glycerol and two fatty acids. Can include a phosphate or an alcohol. Not common in memrbanes, usually modi ed with alcohol. Phosphotidiate with attached alcohol groups (serine, choline, inositol, ethanol amine) Have sphingosine back bone with an acyl chain and a fatty acids. Since they have polarity, the sorters are oriented on the outer part of the bilayer in the ec side > cell surface markers. Modulates membrane uidity based on about of cholesterol. It slips in between phospholipids with polar group oriented out and apolar group in the membrane (alters uidity: lipid biosynthesis (main focus on phosphoglycerides) The backbone of phoshphatidiate (also pre-precursor) is g3p which acts as an acceptor for. Two acyl chains that are installed onto the free hydroxyl groups via ester bonds. Installation of acyl chains catalyzed by glycerol phosphate acyltransferase.
