PSL350H1 Lecture 7: Lecture 7- Protein Targeting Mechanisms in Cells.pdf
Document Summary
Lecture 7: protein targeting mechanisms in cells. How to transport hydrophobic materials to places: we have membrane all over (golgi, It is not that simple the dna makes mrna and then translation: there are clearly trafficking mechanisms. Generate a prediction how fill the cell is (after knowing the sizes of the proteins) There are prediction that there is very little free space. It is crowded diffusion doesn"t work. Need direct targeting because it is too packed. Defects in targeting = lethal due to improper cellular targeting. I- cell disease and zellwenger syndrome has defect in one molecule to be targeted within the cell. I- cell disease (mucolipidosis ii) caused by defect in lysosomal targeting. Cells are complex and full! Ex) a protein that is essential for translation: average speaking, the protein breaks down in a short time. Rbc - no nucleus, simple proteins (heme groups) In protein z, can be turned over within minutes.
