PSL301H1 Lecture Notes - Lecture 3: Complement Membrane Attack Complex, T Cell, B Cell
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PSL301H1 Full Course Notes
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Document Summary
Acquired immunity: antigen specific responses: the body recognizes a particular foreign substance and selectively reacts to it, mediated primarily by lymphocytes, b lymphocytes b cells. Develop into plasma cells, which secrete antibodies: t lymphocytes t cells. Activated t cells develop either into cells that attack and destroy virus-infected cells or into cells that regulate other immune cells: natural killer cells nk cells. Attack and destroy virus-infected cells and tumor cells: all lymphocytes secrete cytokines that act on immune cells, on non-immune cells and sometimes on pathogens. Membrane attack complex creates pores in pathogens: complement proteins insert themselves into the membrane of a pathogen, creating pores, water and ions enter the pathogen cell thru the pores of the membrane attack complexes, cell swells and lyses. Upon first exposure to an antigen, naive lymphocytes reproduce: clonal expansion leads to immunologic memory and short-lived effector cells carry out the immediate response. Antibodies: collectively referred to as gamma globulins, iggs.
