PSL301H1 Lecture Notes - Lecture 13: Coronary Circulation, Ace Inhibitor, Fibrous Cap
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PSL301H1 Full Course Notes
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Document Summary
Cvd risk factors: sex, age, genes, hypertension, cholesterol, stress, smoking, obesity, sedentary lifestyle. To digest ldl and alert smooth muscle cells to proliferate and prevent rupture of endothelium: thick fibrous cap to prevent rupture, small fatty core. Imbalance between oxygen supply and myocardial demand resulting in ischemia. What causes secondary hypertension: chest pain, myocardial creatine kinas and troponin enzyme elevation, st elevation in electrocardiogram, coronary bypass, angioplasty (stent, beta blockers, ace inhibitors, t-pa, lowering blood volume via diuretics, vasodilating via nitroglycerine. Increasing contractibility of the heart by inhibiting na+/k+ atpase. Unknown (accounts for 90% of cases tho : diseases that affect blood flow, damage to vasodilator releasing tissues, damage to sympathetic nervous system. Sudden drop of bp because of quickly standing up. Important sign of circulatory shock for people going through surgery or those in the icu. Systemic vasodilation caused by anaphylaxis or septicemia.
