PSL301H1 Lecture Notes - Lecture 5: Von Willebrand Factor, Thromboxane A2, Prostacyclin
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PSL301H1 Full Course Notes
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Document Summary
Thrombopoietin: vascular, platelet, coagulation, serotonin, endothlin-1, thromboxane a2. Exposed collagen involves von willebrand factor: endothelial cells, platelets, adp, paf, serotonin, thromboxane a2, platelet aggregation forming a plug, vasoconstriction. Active platelets are spiky" for adhesion purposes (adhesion to other platelets: prostacyclin (pgi2, no. What is the difference between thrombus and embolus: thrombin cleaves fibrinogen to fibrin and activates factor 13, factor 13 creates crosslinked fibrin polymers at site of injury. Regulate levels of factor 8: thrombin, factor 7, 9 and 10. Tissue factor results in some thrombin on the surface of smooth muscle cells. Thrombin activates 5, 8 and 11 on the surface of inactive platelets activating them. Active factors on the surface of platelets form tenase and then prothrombinase results in large amounts of thrombin = thrombin burst. Plasmin (active for of plasminogen) breaks down fibrin polymer and is activated by thrombin and tpa which is released by damaged endothelium.
