PSL300H1 Lecture Notes - Lecture 2: Secretion, Ernest Starling, Endoplasmic Reticulum
Document Summary
Not seen as important: at the time, all of the regulation of hormones was though to be controlled by the brain, bran control dominant. Bioassays not available: not valid; some assays were. Chemical separation methods inaccurate: hormones act at vey low concentrations (nm) so separating them is pretty hard, first huge challenge. Insufficient source material: second huge challenge. 1900-1910 face of poland vs england: poland: only neurons important for homeostasis; everything begins and ends with the cns, england: nerves and brain is important but there are also other important mechanisms. Neural control: pavlov and most psychologists (including mcleod from toronto) versus hormonal control: starling leader of splinter group. Bayliss & starling discover secretin in 1902: secretin: hormone that regulates pancreatic exocrine secretion, initially dispute neural control (bayliss) of pancreatic secretions. Reality: both hormonal (slow/sustained) and neural controls required (fast/short term)
