PSL300H1 Lecture Notes - Lecture 14: Analgesic, Potassium Chloride, Action Potential
Document Summary
Membrane potential: sodium, potassium, chlorine ions, action potentials. None posted officially: relevant section (6th edition): they are my suggestions. At rest, membrane is very permeable for potassium. But na and cl ions are also diffusing somewhat. Reason why mp is -70 mv - because of sodium. To calculate actual resting mp, other ions need to be taken into account. From the below equation, which is an extension of the nernst equation: em can be calculated, and is about -70 mv. Permeability of na can be dominant and much more than k - mp can change drastically. Mp is positive inside with respect to outside when accumulation happens. Electrochemical equilibrium would be reached after enough influx of na. Plugging in these new values would result in ena+ = 60 mv. In cell, large proteins are negatively charged so cl is kept outside. So this is not the action of a pump, unlike na and k.
