PSL300H1 Lecture Notes - Lecture 4: Bone Remodeling, Bone Resorption, Tight Junction
Document Summary
Loss of bone density is attributed to less activity by osteoblasts and increased activity by osteoclasts. In a chemical compound o in a receptor complex, eg levels tightly regulated - one of most regulated in the body. A lot because we exchange ca calcium freely and lots is lost daily via urine/feces. Symptoms: tingling in hands or feet unusual muscle jerking/cramps/twitching tiredness, irritable, depressed (in extreme cases muscle tetany of respiratory muscles & asphyxiation) Neural activity bc na channels are more free - more depolarization. Symptoms: increased thirst muscle weakness nausea and loss of appetite kidney & gall stone formation (in extreme cases loss of consciousness and coma) Neural activity bc na channels are less free - less depolarization. Initiator for differentiation is a factor sent by osteoblasts. Osteoclast predecessor binds with osteoblast to create it. Forms a junction, tight junctions near edge of cells. So what happens in the apical side does not get released into bone marrow.
