PSL201Y1 Lecture Notes - Lecture 30: Renal Function, Renal Blood Flow, Podocyte
Document Summary
Afferent arteriole entering the nephron and efferent arteriole leaving the glomerular capillaries. Fenestration slits (capillary pores) between adjacent endothelial cells surrounding the capillaries. 3 layers through which substances need to pass through in process of filtration the capillary pores (fenestrae), then pass through basement membrane then pass through filtration slits. These 3 layers form the glomerular membrane (filtration barrier) Starling forces for glomerular filtration no local energy spent glomerular capillary hydrostatic pressure, bowman"s capsule oncotic pressure, bowman"s capsule hydrostatic pressure, glomerular oncotic pressure. Starling forces favoring filtration across glomerulus glomerular capillary hydraulic pressure. Glomerular filtration pressure = (pgc+pibc)- (pbc+pigc) =16 mmhg it is quite adequate to generate about 125 ml/minute of glomerular filtrate compared to systemic capillaries, the net filtration pressure that generate this is rather larger. Glomerular filtration rate about 65 ml of plasma enters the kidneys per minute and this renal plasma flow of 625 ml can be calculated using a tracer called pah (para-aminohippuric acid)
