PCL481H1 Lecture Notes - Lecture 9: Peroxiredoxin, Glutathione Disulfide, Hydroxyl Radical
26 Feb 2017
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Document Summary
Generated in large amounts by nadph oxidase (nox) in activated macrophages and neutrophils: large amount for ( respiratory burst")- macrophages and neutrophils, smaller amounts in vascular endothelial and smooth muscle cells. Time in which this produced and cell types : respiratory burst that occurs in these cell types . Important event that takes place during infection or invasion. Produced by complexes i and iii of the mitochondrial electron transport chain. Certain amounts of these chemicals and reactive species are being produced. Ros are signaling molecules that tell mechanisms to stay active: cell has made a system to keep ros at a level they can deal with, when invasion occurs ros increases cell can get into trouble. A hexameric membrane-bound enzyme complex (present on out-plasma membrane of cells- macrophages and neutrophils) Present on phagosome and plasma membranes (enzyme is normally latent, but assemble during respiratory burst- early. Normally latent in neutrophils, but assembles during the respiratory burst.
