PCL477H1 Lecture Notes - Lecture 1: Endonuclease, Sister Chromatids, Ap Site
12 Sep 2016
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Document Summary
Because it helps to understand: the mechanism of action for many antineoplastic agents, reasons behind the deleterious effects of environmental agents that causes dna damage. Antineoplastic agents: acting to prevent/inhibit/halt the development of neoplasm. When damage occurs (due to factors as listed above), the cell will have actions such as: cell cycle arrest, dna repair or apoptosis. If none of the actions are working, cell will likely acquire mutations and/or chromosomal damage, which further lead to cancer or lethality. Nucleosome= subunits of chromatin composed of short lengths of dna wrapped around core of histone proteins. Karyotype= chromosomal complement of an individual, describing quantity and quality. Autosome= any chromosomes other than sex chromosomes; we have 22 pairs of autosomes. Aneuploidy= deviation in the normal number of chromosomes. Trisomies=three copies of a given chromosome (when it"s supposed to be two) Monosomy= only one copy of a given chromosome (when it"s supposed to be two)
