PCL302H1 Lecture 6: Lecture 6 - Enzymes II.pdf
28 Sep 2014
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Enzymes ii: drugs that bind reversibly to enzymes (cid:131) ramipril (cid:131) sulfonamides (cid:131) neostigmine. First drug develop and marketed, derived from dyes. Forces involve: hydrogen bond, dipole-dipole interaction, hydrophobic, van der waals forces. When angiotensinogen meet with rein, it get cleaved (cid:131) renin proteolytically cleaves and become angiotensin 1, that angiotensin 1 circulating angiotensinogen to is not active form angiotensin i. In order to be activated, it have to pass the lung, where the lung have a enzyme called (cid:131) angiotensin-converting. Ace enzyme (ace) in the lung convert angiotensin 1 to angiotensin 2. Angiotensin 2 stimulate a number of converts angiotensin i into receptor, including angiotensin receptor and biologically active angiotensin ii increase peripheral vascular resistance by (cid:131) a ii stimulates the at1 receptor causing vasoconstriction. Increase blood to increase peripheral vascular pressure, stimulate the secretion of aldosterone by adrenal glands.
