PCL201H1 Lecture Notes - Lecture 7: Pinocytosis, Active Transport, Aquaporin
14 Sep 2016
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Document Summary
Lecture 7 and 8 mechanisms of drug absorption: review the physicochemical drug properties, examine barriers to drug movement. Functional barriers (transporters: examine mechanisms of drug absorption. Movement through gap junctions: review the physicochemical drug properties. Lipid and water solubility: examine barriers to drug movement. Physical or anatomical barriers include cell membranes and tight junctions. Functional barriers are transport systems that carry the drug out of the cell. The plasma membrane has an unstirred water layer and glycocalyx. Capillaries of excretory/secretory organs have fenestrations (pores) Epithelial and capillary barriers: epithelial cells have tight junction, forcing drugs to pass through cells, most capillaries have maculae, pores that allow passage of large molecules. Transcytosis may occur: other capillaries have fenestrations, transient or long-lasting openings. Molecules >45kda (i. e. protein-bound) cannot pass the basolateral membrane) (need some more clarification on the difference between maculae and fenestrations) Intrathecal injection into csf is an effective way to deliver drugs to the brain.
