PCL102H1 Lecture Notes - Lecture 6: Vasoconstriction, Portal Vein, Hyaluronidase
Document Summary
Local: drug stays at site of administration (topical: speed and duration, bioavailability. Overview and important considerations in drug administration: route of administration: the method by which the drug is introduced into the body, any drug (except those that act topically) must be absorbed into circulation. The proportion absorbed from the site of administration that reaches the circulation unchanged, depends heavily on route of administration. 100% for drugs given iv and less for other methods (e. g. oral) Reduced if incompletely absorbed from site of administration or first- First-pass metabolism: metabolism of the drug in the liver before pass metabolism reaching general circulation: orally administered drugs are absorbed from gi tract and delivered to the liver via the portal vein before general circulation. Winter 2014: bioactivation (prodrug, toxicity, practicality and convenience, other factors, enteral vs. parenteral, enteral: through gi (oral, sublingual, and rectal routes, parenteral: not through gi (injection routes)
