PCL102H1 Lecture Notes - Lecture 6: Ciclosporin, Antibody, Gene Duplication
1 Feb 2018
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Document Summary
Pumps toxic molecules out of our cells. Ways our cells protect themselves from toxins. Use enzymes to convert them into harmless compounds. they sequester them safely out of the way. cells build specialized pumps that find toxins and eject them outside, for safe disposal. P-glygoprotein is the most common molecular pump protecting our cells from toxic molecules. sits in the cell membrane and searches for foreign hydrophobic molecules. When it finds one, it grabs the molecule in a pocket deep within the protein, and then flips to a new conformation. The new conformation has an opening towards the outside of the cell, and the molecule is ejected. The whole process is powered by atp to ensure that everything happens in a timely manner. Needs to be able to eject many different types of molecules. P-glycoprotein pumps hundreds of different molecules, ranging is size from tens to hundreds of atoms. Most are hydrophobic and are normally found in the membrane.
