PCL102H1 Lecture 22: Advanced Issues in Clinical Trials

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Ispy 1 trial: goal: o to identify indicators of response to neoadjuvant chemotherapy (medicines that are administered before surgery for the treatment of breast cancer) that predict survival in women with high risk, stage 2 3 breast cancer o looking at imaging and molecular analysis. What is neoadjuvant chemotherapy: although surgery has traditionally been done before starting chemotherapy, chemotherapy is now more often being given before surgery this is called neoadjuvant chemotherapy, research has shown that there is no overall survival difference if you receive chemotherapy before or after your surgery, there are several advantages to the neoadjuvant approach as a choice for therapy o for women with large tumours, neoadjuvant therapy may shrink the tumour enough to allow you to have more surgical choices o learning whether or not your tumours has responded to chemotherapy can help you and your o doctors determine if you need any more treatment after surgery.

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