PCL102H1 Lecture 14: A History of Drug Discovery

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Setting the scene: the (cid:271)la(cid:272)k death (cid:449)iped out al(cid:373)ost half of the populatio(cid:374) of europe i(cid:374) the (cid:1005)(cid:1007)(cid:1008)(cid:1004)"s, killi(cid:374)g 7(cid:1009)-200 million people throughout europe and asia. If we could diagnose and treat every patient, then hiv/aids could be conquered in a generation. Isaac newton publishes his laws of motion and gravitation: edward jenner starts vaccination for smallpox. 1799: president george washington has got a chill after being out in the rain, he wakes in the night feeling unwell a local bleeder is summoned who takes a pint of blood from. Aquarius: saturn + jupiter = death and disaster, mars + jupiter = pestilence, jupiter = warm and humid, drawing up of evil vapours, mars = hot and dry, kindles the infective fire. If in doubt, include more ingredients the more elaborate and complex a medicine, the better it is bound to be: theriac (publicly brewed in venice in 1645) an antidote to all imaginable poisons and ills.

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