PCL200H1 Lecture Notes - Lecture 7: Cannabinoid Receptor Type 1, Cannabinoid Receptor Type 2, Periaqueductal Gray
12 Dec 2019
School
Department
Course
Professor
Document Summary
1964 - isolate thc from hashish and determine that it is the chemical in cannabis that causes high . 1988 - discover the location of cb1 receptor (rat brain) 1992 - discover anandamide - the rst endogenous cannabinoid. 1995 - 2-ag - the second endogenous cannabinoid discovered. Thc - stays around, doesn"t get degraded, sticks around in tissue when you"re not high anymore. Thc vs endocannabinoids ecbs: quickly degraded - fast acting modulators to correct level of neurotransmission, promotes bone formation appetite stimulant reduces pain (part of descending pathway) promotes earning and memory. Long lasting - acute effects last hours, accumulates in fat tissues and remains in body for weeks: appetite stimulant and anti emetic, reduces pain (analgesic) and muscle spasticity, hallucinations (sensory and time distortion) Phytocannabinoids - thc: euphoric, munchies, analgesic, anti-emetic, memory loss, hallucinations. Cbd: anti-epilepsy, anti-psychotic(?, anti-cancer(?) does not cause high". Endocannabinoids appetite stimulant pain processing leaning and memory bone formation pain relief in multiple sclerosis.
