NFS382H1 Lecture Notes - Lecture 5: Zinc Transporter Protein, Acrodermatitis Enteropathica, Alkaline Phosphatase
Document Summary
Human body contains 1. 5-3. 0 grams of zinc. Found in all organs, tissues, and body fluids. Found in several valence states but must often as divalent ion (zn2+) Red meats, seafood, poultry, pork, dairy (provides up to 70% of zinc in diet of americans) In food, usually in a complex with nucleic acids and amino acids: organs (such as liver) have a lot of vitamins and minerals. Whole grains (especially bran and germ), vegetables. Availability negatively affected by heat, maillard reaction products (cook amino acids with reducing sugar this will bind to zinc and decrease its bioavailability) Zinc supplements topical (wound healing), oral. Hydrolyzed from amino/nucleic acids in stomach & small intestines. Occurs primarily in the proximal small intestine by either a carrier mediated process or diffusion. Carrier-mediated process (7-9 mg/d physiological concentration: zrt- & irt-like protein (zip) 4 between cells. In cells, zn may be used functionally or stored in vesicles, in the trans-golgi network, or as part of metallothionein.
