LMP410H1 Lecture Notes - Lecture 4: Histology, Gamma Secretase, Morris Water Navigation Task
31 Mar 2016
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Late onset progressive loss of memory, reasoning and judgement, ability of complex tasks and aciviies of daily living. Prevalence progresses with age more now cuz of the baby boomer era so we have an increasing populaion age and therefore we have an increasing prevalence there isn"t a populaion protected from ad. The cell types that typically die are the ach neurons amyloid plaques are dense cores surrounded with dead neurons. Second pathology is neuroibrillary tangles (nft) which is accumulaion of tau protein. These enzymes (on slide) we use alpha secretase pathway more and less toxic material is cleaved and pumped out beta secretase pathway is the toxic one and there is aggregaion and precipitaing out. All mutaions around the a beta pepide which increases its ability to aggregate and therefore forming the amyloid plaques there is a mutaion that protects (icelandic family has this mutaion) Because when ab is a monomer which is randomly.
