IMM250H1 Lecture 9: Lecture 9
Document Summary
Acute upper respiratory infection; fever cough, muscle ache; more severe in very old, very. Virus starts replicating in epithelium of upper air ways young and those with chronic conditions can lead to death. Spread through small particle droplets lodge in upper airways or direct contact. Influenza virus: negative strand rna virus: ha hemagglutinin (h1-h16) Enveloped sheathed in lipid bilayer has 8 rna segments: Enzyme needed to get virus off cell: na-neuraminidase (n1-9, m-matrix-m1, m2, np-nucleoprotein (holds nucleic acid together, ns-non-structural- ns1- counteracts host response, ns2-nuclear export, other functions, ps, pb1, pb2-rna polymerase. Virus ha attaches to terminal sialic acids on surface carbohydrates; ha changes. Why do we constantly need new vaccines? conformation to cause virus envelope fusion with endosome membrane and release of viral contents into cytosol; virus is not systemic (does not spread to other parts of body like avian flu)
