IMM250H1 Lecture Notes - Lecture 8: Immunoglobulin Class Switching, Memory B Cell, Isotype (Picture Language)
Document Summary
Na ve b cells require 3 signals for successful activation: antigen recognition (bcr recognizes specific antigen through direct engagement, cell-cell contact (interaction between cell surface molecules of b cell and effector th, cytokines (from effector th; proliferation/differentiation signals) Na ve b lymphocytes lymphocytes enter from blood via hev; b cells migrate to the cortex and form follicles; effector th cells that that remain in the node migrate from paracortex into the cortex. How th cells provide help to activate b cell: Antigen epitope binds to bcr on b cell (signal 1) B cell acts as a apc (internalizes and degrades that antigen and displays peptide on mhc. Effector th recognizes peptide forms b-t conjugate class ll) Th delivers help to antigen specific b cell intermolecular contact (signal 2); th effector cytokines (signal 3) Antigen specific b and t cells interact at the border between the follicle and paracortex form. Conjugates and stick together (move quite fast; have high attraction)
