IMM250H1 Lecture Notes - Lecture 5: Adaptive Immune System, B Cell, T Cell

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28 Jan 2016
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Innate immunity has no memory and responds the same regardless of frequency of antigen encounter vs adaptive immunity whose responses rely on memory as # of encounter increases, responses are of faster magnitude. Only jawed vertebrates have an adaptive immune response. Lymphocytes do not recognize pamps/damps recognize antigen and must be told by innate system to respond. B lymphocytes (b cells) express b cell receptors (bcr) T lymphocytes (t cells) express t cell receptors (tcr) Antigen receptors on a given lymphocyte are identical, highly specific for antigen, unique to that lymphocyte. V domains high amino acid variability from lg to lg. C domains low amino acid sequence variability from lg to lg. Tcr cannot be made in secreted forms, bcr can be secreted. Bcrs bind directly to intact antigens (epitopes are usually on surface of pathogen) Tcrs bind only a small fragment of antigen that must be presented by a host cell.

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