IMM250H1 Lecture : Notes taken during lecture
Document Summary
Role of positive selection in shaping the tc repertoire. Then accessory activation molecules cd4 and cd8 good correlation between cd4 expression and function of helper or expression of cd 8 and killer cell function. But not 100 percent correlation expression of cd4 and mhc class 2 restricted tcr correlates perfectly; ditto for cd8 and mhc class 1 restricted tcr. White lie is alloreactivity mhc is source of a thousand antigens to tcrs within the species. Thymic epithelium positively selects mhc function, negatively selects for t cells able to recognize self with high affinity if these mature, and exit thymus into periphery, autoimmune disease. Through chimeras, can dissociate mhc expressed by tc from that which restricts its function. P1 into f1 complete association p1 mhc function restricted by p2 mhc convinced that mhc restriction is receptor ligand interaction. H-2 d+x antigen is associated with h2d. But h2d also means it has peptide, a self peptide that is not x.
