IMM250H1 Lecture Notes - Lecture 10: Upper Respiratory Tract Infection, Rna Virus, Respiratory Tract Infection
Document Summary
Successful: smallpox eradication ~ who campaign 1979, polio ~ next who target, measles, mumps, rubella, chicken pox, human papilloma virus (hpv) 70% of human cervical cancer ~ new vaccine. Lack of e ective vaccines: hiv, tb, malaria, in uenza. Symptoms: fever, cough, muscle aches, more severe in old, very young, chronic conditions, lead to hospitalisation, 2 infections, death. How is it spread: particle droplets in airways. Virus starts replicating in epithelium of upper airways: direct contact, more prevalent in winter. Droplets can move through air in cool dry conditions. When humid and hot - droplets larger and settle faster (need more direct contact) In uenza are orthomyxoviruses: di erent forms (pleomorphic, cause febrile respiratory illness with systemic symptoms. Di erent subtypes, strains within subtypes (eg. h1n1, h3n2: in uenza b. Di erent lineages, strains within lineages (eg. b/yamagata, b/victoria: in uenza c.
