IMM250H1 Lecture Notes - Neutrophil, Oncogene, Thymocyte
Document Summary
Recognize antigen using variant t cell receptors. Uses invariant cd3 chains to transduce signalling required for t cell differentiation and signalling. Two patients were enough to demonstrate this concept. Immune system is important for fighting infections and controlling itself may have disregulation with large spleen, large liver, large lymph nodes: susceptible to infections and overactivation of immune system. Founder effects especially in small communities. Family members tend to marry each other found effects there. Ada deficiency confers some resistence to malaria common in somali. Absolute number of lymphocytes would not have led to diagnosis in both patients: best diagnosis is absence of t cells. After excluding secondary causes of immunodeficiency like hiv, malignancy. And determine which lineage of t cells involved. Absence or presence of these different lineages help identify the specific cause of immune deficiency. Which specific lymphocyte lineage is affected helps identify the specific cause of the immunodeficiency.
