IMM250H1 Lecture Notes - Lecture 11: Thymocyte, Mhc Class I, Mhc Class Ii
Document Summary
1/20 people in western countries suffer, which is higher than developing country. Non-specific (global immunosuppression susceptible to opportunistic infections) Type i diabetes requires daily injections of insulin. Rheumatoid arthritis requires daily therapies to keep the inflammation in joints under control. High burden to health care system and economy. Organ-specific autoimmune diseases attacks particular tissues: type 1 diabetes mellitus = pancreas, multiple sclerosis = cns. B cells can cause autoimmune diseases as well. Four mechanisms of maintaining t cell tolerance. T cell precursors migrate from the bone marrow to the thymus. T cells precursors in the bone marrow migrate to the thymus to finish development. B cells develop and finish development in the bone marrow. At puberty, the thymus involutes and becomes smaller. A lot of the thymic education takes place in the first decade of life. It continues to take place in adults but not as efficiently.
