HMB300H1 Lecture Notes - Lecture 4: Protein Kinase C, Entorhinal Cortex, Synaptic Tagging
Document Summary
Recap from last lecture: short-term memory is all about the ampars moving, what about long-term memory, memories and consolidation one potential candidate for the job pkm . Systems consolidation, where synaptic strengthening that has occurred within the hippocampus, and is then transferred to other parts of the brain (i. e. as memory traces), was derived in large part to the work of drs. What we know (and don"t know: believed that the hippocampus will then activate these particular groups of neurons in the cortex when it retrieves a memory. How it does so is still largely unknown. Entorhinal cortex damaged in alzheimer"s disease: also evidence to suggest that the entorhinal cortex is involved in repetitive or incremental types of learning (e. g. multiplication tables) If memories and learning are to last long periods of time, what is the mechanism: current hypothesis is that long term memory formation requires ltp, synaptic tagging and eventual protein synthesis.
