HMB300H1 Lecture Notes - Lecture 3: Mania, Interferon, Frontal Lobe
Document Summary
Need to be able to prove things: do gut bacteria regulate the hallmark motor deficits and pathophysiology of synucleinopathies, earliest signs we see are actually related to the gut! Triton: can look at either soluble/insoluble portion of syn, in the gf mice, the insoluble portion is almost non-existent, if it was a pd patient, biggest cure! Not having clumping of alpha synuclein would help a lot of things: cp-caudoputamen, sn-substantia nigra. Syn-dependent microglia activation: if we cut vagus nerve, it delays symptoms of. You can actually do gut/fecal transplants, becoming much more common now . Scfas: scfas by themselves, without doing anything else to microbiome, is enough! A lot of these things don"t translate well . Scfa: a number of genera were altered in animals colonized with microbiota derived from. Midlife vs late-life depressive symptoms and risk of dementia: **measure inflammation via crp (c-reactive peptide) if elevated, humans.
