HMB265H1 Lecture Notes - Lecture 4: Wild Type, Chromosome, Genotype
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HMB265H1 Full Course Notes
Verified Note
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Document Summary
Lecture 03 molecular basis of genetic polymorphisms & Only mutations in germline cells can be transmitted. Forward mutation change wild-type allele to a different one. Reverse mutation novel mutation to revert to wild type. Deletion block of one or more dna pair is lost. Insertion block of one or more dna is added. Reciprocal translocation part of nonhomologous chromosome change places. Chromosomal rearrangements affects many genes at one time. Dna mrna protein organismal traits. Allelic differences at the dna level can influence mrna expression and/or protein function and thus phenotype. There is no dominance and recessiveness at the dna level, since it is the underlying genotypic basis of inheritance (codominance) Haplosufficient: 50% of protein is enough to give wild-type. Haploinsufficient: 50% of protein is not enough to give wild- type. 50% wt is enough to function. 50% wt is not enough to function.
