HMB200H1 Lecture Notes - Lecture 2: Radial Glial Cell, Synaptic Pruning, Neuroblast
Document Summary
Glossopharyngeal: tongue and pharynx movement and sensation. Vagus: heart, blood vessels, viscera, movement of larynx and pharynx. Nature (development of brain) = influenced by nurture. Synaptic pruning/elimination of axons and cell death. *synaptogenesis and synaptic pruning susceptible to variability* Nervous systems start out as long hollow tube. Layer doubles, one layer forms inner surface. Inner surface contains stem cells that divide and differentiate into radial glia - glial cells that send radial processes to outer surface. Stem cells keep dividing - neuroblasts migrate along radial glia. Stem cells in ventricular zone also produce neuroblasts that migrate various distances and can send axons radially or laterally. Cerebral cortex comes from 6 layers closest to outer surface. White matter - all the (myelinated) axons within the center zone that once contained the radial glia, many axons that projected laterally. Connections form complex folded structure that exists through radial glia.
