CSB332H1 Lecture Notes - Lecture 17: Orbitofrontal Cortex, Autoreceptor, Exocytosis
25 Apr 2014
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Document Summary
When stress is chronic, you can"t have any sort of control over the stressors. The dorsal medial cortex is analogous to the dorsal part of the medical prefrontal cortex in rodents. It has been shown to be involved in our ability to have a sense of control and predictability of the stressors that we experience. People who don"t respond to the symptoms would eventually experience psychiatric disorders. If the stressors are moderate and the dorsal medial prefrontal cortex understands that you have the resources to easily address the stressor, then you can easily habituate, especially if the stressors are predictable and controllable. Habituation is mediated by the endocannabinoid system (e. g. , 2-ag). If the stressors are chronic and unpredictable, then you don"t give your body to habituate. The demands of the hpa axis cannot be addressed properly, so you are unable to habituate from these stressors, which results in problems (e. g. , ptsd).
