CSB351Y1 Lecture Notes - Lecture 20: Polio Vaccine, Flaccid Paralysis, Muscle Atrophy
26 May 2016
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Document Summary
So polio used to be a thing: ubiquitous vaccination has mostly eradicated it from the world. But not completely, still flares up in the middle east/south asia: been around forever. Polio as a template: enteroviruses: specific type of picornavirus, polio rapidly mutates in the gut, but is stable outside. Hence, we can use polio vaccines from the 1950s and they"d still work. And we don"t need boosters: polio is paralytic because it moves to the brain. Others move to skin, muscle or liver (foot and mouth, myocarditis, hepatitis a: transmission of polio. Infection can create viremia, but most growth is in gut. Galt: gut associated lymph tissue, polio grows in galt for five weeks. Herd immunity: enough immunizations mean polio dies out before it can find a host. Sanitation: clean out the feces, that would help. Some people are asymptomatic carriers: clinical features of infection/pathology. Asymptomatic (90%: virus only in mouth, throat, gut.
