CSB328H1 Lecture Notes - Lecture 20: Thoracic Vertebrae, Cervical Vertebrae, Axial Skeleton
28 Aug 2019
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Document Summary
Axial skeleton: hox genes responsible for making differences between different region bones and specific identity of vertebrate. Hox4 cervical; hox6-8 thoracic; hox10 lumbar; hox11 & hox10 sacral; caudal: hox genes cause regional differences in the vertebral column, hox genes cause morphological differences of vertebrae within a region. Do hox contribute to changes in the body plan between species: giraffe vs rhea (flightless bird) Giraffe made up of only 7 cervical vertebrae (like other mammals) Hox 6 also being expressed in same areas despite cervical/thoracic area. Hox 6 being expressed in same regions (between c-t, same patterns as mouse: hypothesis function of hox genes is conserved. Hox6 might control thoracic identity, hox10 lumbar identity in both species. Unusual body plan of snakes: no limbs and homogenous phenotype, only a short cervical region, elongated thoracic region, no lumbar region, some caudal region in snakes. Hoxc6 is not expressed throughout the whole thoracic region but overlaps with hoxc8 (posterior region of thoracic)
