CSB328H1 Lecture Notes - Lecture 15: Myosatellite Cell, Signal Transduction, Histone H2B
4 Nov 2016
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Fgf signalling pathway activates muscle stem cells to divide for growth or repair: starts with ligand binding to receptor which gets phosphorylates, receptor dimerizes and interacts with gef which causes ras to release gdp so. If you have no gef, then ras cannot be activated and the signal transduction cascade is not active and pathway is not active. Then the muscle stem cells will not go into division. If we have no gap, the ras remains in its active gtp-bound form and that"s called constitutively active ras because its always active. If ras is always active, the pathway is always active and the cells keep dividing and proliferating and that can lead to cancer. 2012 paper: young mice are better muscle builders than old mice: satellite cells divide more often in old mice, increased loss of satellite cells in old mice, experiment. Fed the mice dox which allows the mice to produce h2b::gfp and more.
