CSB328H1 Lecture Notes - Lecture 6: Gastrulation, Neuroectoderm, Notochord
24 Oct 2016
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Forms endoderm (which will form the gut later on: vegt: transcription factor. Activates sox17 -> important for the specification of the endoderm the inherited factor that determines (cid:272)ell"s fate i(cid:374) this (cid:272)ase, it"s vegt (it deter(cid:373)i(cid:374)es the fate of those (cid:272)ells a(cid:374)d tur(cid:374)s them into endoderm) Activates genes that regulate noda-related proteins (that diffuses into the neighbouring regions) to induce mesoderm induction. Ex. of conditional specification (cells instruct/help each other to take on: nieuwkoop dis(cid:272)o(cid:448)ered that a particular cell fate) The dorsal vegetal regions are different in its properties from the ventral vegetal regions. Nieuwkoop centre (dorsal vegetal zone: contains (2 factors) vegt and beta-catenin, corporate to produce large amounts of nodal-related proteins. Recall: dorsal mesoderm was where the dorsal blastopore lip formed. This lip has unique properties for development of embryo. Move very actively into the embryo, this movement it important for the movement of mesoderm into the embryo as well.
