BCH210H1 Lecture Notes - Lecture 15: Acetyl-Coa Carboxylase, Malonyl-Coa, Acetyl-Coa

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Cecilia Kutas

Document Summary

Naturally, after this heavy meal, insulin rises in the blood and drives fat synthesis in liver. Insulin will be released from pancreas to deal with rise in sugar. Liver readily converts glucose into pyruvate via aerobic glycolysis: forms acetyl coa, co2, and nadh. Fat synthesis takes place in the cytoplasm. Atp- citrate lyase breaks down citrate to reform acetylcoa and oxaloacetate. Enzyme that carboxylates acetyl coa malonyl coa cytosolic, polymeric enzyme that carries 2 reactions contains biotin cofactors and requires atp. Malonyl coa is made by acetyl coa carboxylase (acc) in the cytoplasm, using atp as an energy source. Acetyl coa + atp + hco3- malonyl coa + adp + pi + h+ Malonyl coa is the supplier of 2c units in fa synthesis. Transcarboxylase: transfers co2 group onto acetyl coa. Contains biotin cofactors and requires atp. Final fa product- product inhibition. Insulin also profoundly inhibits hormone sensitive lipase in fat cells and shuts down fat mobilization.