PSYC62H3 Lecture Notes - Lecture 7: Succinic Semialdehyde, Ghb Receptor, Sodium Oxybate
Document Summary
Ghb can be synthesized from a precursor commonly found in paint thinner (gamma-butyrolactone gbl: innate sources. Begins with activity of ghb dehydrogenase: synthetic sources. Metabolized to ghb by lactonase enzymes: cns effects. High doses lead to more severe symptoms of confusion, somnolence, coordination, episodic amnesia (nefarious use) Loss of consciousness, hypotension, and bradycardia, respiratory arrest/asphyxiation. Fatigue, confusion, memory dysfunction, anxiety, insomnia, vertigo. Inhalants: volatile substances with psychoactive properties, repurposed from home or workplace products, some have clinical purposes i. e. anesthetic and vasodilation, volatile solvents are the most abused, i. e. Toluene, xylene, butane, ethylene: adolescents represent the largest portion of inhalant users, only class of substance that is abused by younger vs. older teens, local impact. Native children of davis inlet: routes of administration, pharmacokinetics. Rapid absorption and distribution within cns why might this be: similar cns effects as ethanol. Gabaa + modulation: effects vary across time.
