PSYC62H3 Lecture Notes - Lecture 3: Intramuscular Injection, Insufflation, Half-Life
Document Summary
Pharmacokinetics: how drugs move through body // pharmacodynamics: how drugs cause biological changes. Pharmacokinetic properties and drug passage through the body. Absorption: entry of a drug into the circulatory system. Depending on route of administration, the drug must pass through different membranes. Most therapeutic drugs are orally administered (much easier) But oral administration route creates challenges: gastrointestinal system breaking down substances. Distribution: passage of a drug through the body (intramuscular injection: takes longer time for the drug to get absorbed and distributed around body) Affects a drug"s (cid:271)ioa(cid:448)aila(cid:271)ilit(cid:455) (cid:894)a(cid:271)ilit(cid:455) of the drug to rea(cid:272)h site of a(cid:272)tio(cid:374)(cid:895) For psychoactive drugs, bioavailability depends on the drug reaching the cns. Nonspecific binding may interfere with permeation of bbb (e. g. binding to another protein due to affinity / charge ) Polymorphisms for these enzymes can have higher ratio of certain enzyme. Affect the ability to metabolize certain drugs.
