NROC69H3 Lecture Notes - Lecture 5: Afterhyperpolarization, Parvalbumin, Dynorphin
Document Summary
Basal ganglia: a group of interconnected subcortical nuclei in the mammalian forebrain and midbrain. None of the nuclei are directly connected to the sensorimotor organs. However, the basal ganglia are commonly linked to the control of movement implicated in neurodegenerative diseases associated with the basal ganglia: parkinson"s, rigidity, pausity of movement, huntinton"s, emission of unintended movements. Basal ganglia has multifaceted functions: motor control, reward learning, executive functions, working memory, behavioral flexibility, sensorimotor integration, limbicmotor integration. Common theme in basal ganglia: involved in the selection of certain motor plans, strategies, goals, sensory and limbic information, while inhibiting others. Basal ganglia components: striatum, caudate nucleus, putamen, globus pallidus, subthalamic nucleus, substantia nigra. Striatum: largest part of the basal ganglia, the main input nucleus receiving excitatory glutamatergic input from the cortex (corticostriatal inputs) and thalamus. Nucleus accumbens: known as the ventral striatum, plays an important role in learning and motivational processes (limbic-motor integration)
