HLTB22H3 Lecture Notes - Lecture 4: Genomic Imprinting, Histone Deacetylase, Epigenetics
Document Summary
What is epigenetics: c. h waddi(cid:374)gto(cid:374)(cid:859)s origi(cid:374)al concept, describes interaction between cell differentiation and genetic mutations during development. Also described what would become the field of molecular development: d. l nanney in 1950s. Unless you are also describing the situation in the first point, you should not call this epigenetic, even if you think it makes your research sound sexier. Epigenetic modification: occurs through, covalent modifications of dna, proteins that form from scaffolding for dna packaging. Mechanisms of epigenetic modification: methyl groups attached to the cpg islands regulate gene activity, groups attached to histone tails determine the activity of the dna wrapped around them, chromatin remodelling makes certain regions of dna available for transcription. These mechanisms allow rna polymerase to initiate transcription: drivers of epigenetic modifications, cell differentiation during development, changes that occur throughout life span. Inactivation of x chromosome: x inactivation in females (lyonization).
