HLTB22H3 Lecture Notes - Lecture 10: Cancer Cell, Cell Division, Genome Instability
Document Summary
Tumour: a defect in rate/ability/control in cell division, a disease which self proliferates, genetic change as because genetic change causes change in phenotype, one mutation moves through cell division continuously (proliferation) Accumulation of the cells is what causes a problem. From alberts molecular biology of: probably a multi hit disease. Don"t just need one thing to make the cell abnormal. One event creates abnormal cell; proliferates causing more abnormal cells. Tuesday, november 22, 2016: another modi cation may cause it to thrive more or die out, results in faster or slower progression of cancer. Colorectal cancer - adenoma to carcinoma progression: believed to be due to multi-hit in icts. Apc - adenomatous polyposis coli tumour suppressor gene. Kras - kirsten-ras g protein (hint: recall lecture 1) Kras-variant (mutation) and caner: under normal conditions, can be controlled by binding microrna. Controls production of kras protein: variant causes the microrna to not be able to bind to gene.
