HLTB11H3 Lecture Notes - Lecture 8: Adipose Tissue, B Vitamins, Acrostic

96 views16 pages

yellowdonkey422

19 Mar 2019

School

Department

Course

Professor

For unlimited access to Class Notes, a Class+ subscription is required.

Document Summary

A: not stored in the body, b vitamins and vitamin c, are rapidly depleted (except for b12 which is ef ciently conserved for several years) so need to be consumed regularly. Excess amounts consumed are excreted in the urine. Can be stored in the liver and adipose tissue. Are not rapidly depleted from the body. If intake is extremely high can have toxic effects. ; to increase the amount of a nutrient in the food supply: labelling. If a nutrient has been added to a food then it has be listed in the nutrition facts tables. Storage and excretion of vitamins: water-soluble vitamins. Exception: vitamin b12 stays in body for several years: fat-soluble vitamins. Excess amounts more toxic than water-soluble vitamins. Protection from oxidative damage or oxidative stress. Thiamine isolated as cause in early 1900"s. Monday, march 11, 2019: alcohol depletes thiamine. Widespread in foods, best source in canada is milk.

Related Questions

The people of Malaysia belong to three communities: the local people called Malays, immigrants from South India called Tamils, and immigrants from China. During the early 20th century, the Malays lived mainly in coastal villages, the Tamils worked on rubber estates, and the Chinese worked in tin mines. In general, the people were very poor and they consumed a limited variety of foods.[1] Rice was the staple diet of all three communities and therefore the key source of caloric and nutrient content. Malays typically grew their own rice and dehulled it before consuming it; dehulling partially removes the aleurone layer of the rice seed. Following their South Indian food habits, the Tamils ate parboiled rice, and the Chinese ate polished white rice imported from Thailand. It was found that among the three Malaysian communities, the Chinese community was much more prone to suffer from some degree of sub-optimal thiamin intake. Out of every 1,000 Chinese inhabitants, about 120 had mild thiamin deficiency, about 80 had severe thiamin deficiency, and about 16 people had died of it. Suboptimal intake of thiamin was rare in Malays and was not reported at all in Tamils.[1] Thiamin, also called Vitamin B1, is required for all tissues, and its deficiency causes the disease Beriberi. Less severe deficiency results in non-specific symptoms such as weight loss, malaise, irritability, and confusion. Although the origin of the word Beri-beri is disputed, it is believed to be a Philippine word meaning âI canât, I canâtâ and was probably coined to refer to the lack of neuromotor coordination in people afflicted with this disease.[2] Thiamin is water-soluble and is stable in the acidic medium. It is unstable to heat, oxygen, and UV light in neutral and alkaline medium. The active form of thiamin is thiamin pyrophosphate (TPP). This active form is a cofactor for pyruvate dehydrogenase and transketolase enzymes that are involved in the metabolism of carbohydrates. These enzymes play an important role in the biosynthesis of a number of cell constituents such as neurotransmitters, pentoses, and reduced equivalents, used in oxidant stress. The human body cannot store thiamin and therefore requires a continuous supply of the vitamin. The thiamin in an individual on a thiamin-free diet typically depletes in fewer than two weeks. Thiamin absorption is affected by compounds, called thiamin antagonists or anti-thiamin factors, that alter the structure of thiamin. These compounds include alcohols, polyphenols, flavonoids, and thiaminase, a heat labile enzyme found in certain foods.[2] In affluent countries, where the diet is rich in thiamin, the most common cause of thiamin deficiency is excessive alcohol consumption. Alcohol intake affects thiamin status in two ways. First, alcoholics get a significant percentage of their daily energy intake from alcoholic beverages, which are nutrient deficient. In other words, alcoholics replace their consumption of nutrient dense foods that are part of their normal diet with the consumption of nutrient deficient alcohol. Second, alcohol inhibits the intestinal ATPase involved in the absorption of thiamin.[4] Sub-clinical thiamin insufficiency associated with excessive alcohol consumption produces an encephalopathy called Wernicke-Korsafoff syndrome. Patients with this syndrome have a higher than normal incidence of abnormal transketolase, which has a very low binding affinity to TPP. This problem can be overcome by putting patients on high-dose thiamin therapy. Some patients, however, might have a form of abnormal transketolase that does not bind at all with TPP. Such people do not respond to high-dose thiamin therapy.[4] Thiamin deficiency is observed in individuals who have low thiamin intake and a diet rich in polished rice, especially if their diet also consists of anti-thiamin factors such as tea, coffee, raw fermented fish, and betel nuts. The minimum amount of thiamin needed by the body can increase because of increased physiological or metabolic demands arising from pregnancy and lactation, heavy physical exertion, illnesses like cancer, liver diseases, hyperthyroidism, and surgery. Since TPP is required for carbohydrate metabolism, the recommended dietary allowances for thiamin are based on the assumption that its intake is related to total energy intake. The recommended dietary allowance in the United States is 0.5 mg/1000 Kcal.

Questions
1. Thiamin deficiency was observed only in the Chinese community even though all three
communities had the same staple (rice) diet. Explain.
2. On packages of enriched rice sold in supermarkets, the rice preparation directions state that the
rice should not be washed before cooking. Explain.
3. Severe metabolic acidosis caused by high levels of lactate is often associated with thiamin
deficiency. Explain.
4. Provide two plausible explanations for what might cause above normal levels of pyruvate in blood
and urine. How can one determine which of the two explanations is correct?
5. Why does thiamin utilization increase among cancer patients?
6. A negative correlation exists between the need for thiamin and the amount of fat in the diet.
Explain.

taupehound665

Please help me check my answers and correct them if needed.Thank you!

1. Which statement regarding malnutrition is true?

	Malnutrition of one nutrient may directly and indirectly affectonly one system
	All nutrient deficiencies typically manifest in a matter of daysor weeks.
	Most cases of malnutrition in the elderly are directly relatedto a loss of appetite
	Nutritional homeostasis should primarily be achieved bydietary alterations.

2. Movement of the stomach/stomach lining upward into esophagusor diaphragm is termed what?

	Gastric reflux
	Gastric torsion
	Hiatal hernia

3. Which of the following is a function of the liver?

	produce and secrete insulin
	produce and secrete glucagon
	metabolize drugs
	excrete drugs from the body
	store red blood cells

4.
Which of the following regarding malnutrition is true?

	ingestion of supplements will prevent malnutrition
	malnutrition can be avoided if the recommendations of the foodpyramid are followed
	malnutrition in the United States is rare

5. What is protein-carbohydrate malnutrition? A person who:

	doesn't eat enough protein or carbohydrates
	eats to much protein and not enough carbohydrates
	eats to much carbohydrates and not enough protein
	eats to much protein and carbohydrates which interferes withabsorption and digestion of other nutrients

6. Which vitamin is stored in the tissues?

	A
	B
	C

7. The menstrual occurs within 3 or 4 days of which of thefollowing changes in the blood?

	increase in estrogen and decrease in progesterone
	increase in progesterone and decrease in estrogen
	increase in progesterone and estrogen
	decrease in progesterone and estrogen

8. Which statement regarding sperm production and aging istrue?

	Aging increases the amount of sperm produced
	Aging has a variable effect on the amount of spermproduced.
	Aging causes major changes in sperm cell morphology
	Aging causes major changes in sperm cell function

9. Which of the following is a function of the digestivesystem?

	Helping with speech
	Vitamin A production
	Storing blood in the pancreas
	Producing erythropoietin

10. Thinning of the enamel, decrease in nerve cells, recedinggums and loss of muscle of mastication coordination are consideredto be what type of changes in the mouth?

	Abnormal changes
	Age changes

11. A decline in sexual activity with age is primarilyassociated with what age related changes in the physiology of amale?

	Decline in frequency of use
	Deteriorating self-image
	Medication use
	Changes in blood flow

12. Which of the following conditions is not apathological change that effects the stomach?

	Peptic ulcer
	Atrophic Gastritis
	Acute Gastritis
	Stricture

13. Which of the following is an age related cause for fecalincontinence?

	Laxative use
	Ulcerative colitis
	Colorectal cancer
	Disability
	Stool softener

14. A decrease in lactase secretion is an age related changeassociated with the _____________.

	stomach
	small intestine
	large intestine
	pancreas

15. Which of the following statements regarding atrophicgastritis is true?

	causes overproduction of HCL
	causes overproduction of intrinsic factor
	increase absorption of B12
	increase risk for cancer

16. Functional incontinence may be due to a problem withwhat?

	cognitive function
	autonomic system
	urinary bladder
	urethra

17. Which of the following is not a function of nutrients?

	energy for activities
	raw materials for growth
	buffer to maintain pH
	fluid and electrolyte balance

18. Adenosine triphosphate is produced during all of thefollowing processes, except ______.

	Oxidative phosphorylation
	Kreb's cycle
	Electron transport
	Glycation

19. The digestive system helps create nutritional homeostasis,which of the following is one of the four reasons for nutritionalhomeostasis?

	nutrients are formed to supply the energy for vitalfunctions
	nutrients supply raw materials to synthesize body substances
	nutrients counteract against blood so that volume ismaintained
	nutrients tear down worn out substances for later use

20. Women with _____ percent body fat has an increase risk for ashorter life span and weight related diseases.

	18
	22
	27
	31

21. What amount of protein should be consumed daily by an olderadult?

	.25 gram per kilogram of weight
	.5 gram per kilogram of weight
	.75 gram per kilogram of weight
	1 gram per kilogram of weight

22. Stress incontinence is much more common in women than in menbecause women have which of the following?

	longer urethra
	premenopausal thinning
	weakened structures

23. Which of the following is an age related change affectingthe kidneys?

	increase in weight
	increase in width
	decrease in area
	decrease in volume

24. Postmenopausal decrease in estrogen leads to age relatedchanges of the _________.

	Urethra
	Urinary bladder
	Ureter
	Kidney

25. _______ percent of the working capacity of both kidneys isneeded to maintain homeostasis.

	10
	20
	30
	40

26. Which of the following is considered a treatment for urinaryincontinence?

	surgical removal of the sphincter
	medications to modify bladder function
	electric shock therapy

27. Which reproductive hormone provides a decrease risk ofatherosclerosis?

	testosterone
	relaxin
	estrogen
	follicle stimulating hormone

28. Which form of cancer in the female reproductive system rankssecond in occurrence?

	Ovarian
	Cervical
	Endometrial
	Vaginal

29. Which hormone produced in females seems to stimulate thelibido?

	Estrogen
	Progesterone
	Testosterone
	Luteinizing hormone

30. Which of the following regarding prostate cancer istrue?

	it is related to having benign prostatic hypertrophy
	it is more common in white males
	testing for prostatic specific antigen is sensitive andspecific
	it impairs the function of the liver

azureelephant219

Please check and correct answers that are bolded, thankyou