CHMB42H3 Lecture Notes - Lecture 10: Imide, Aminolysis, Gabriel Synthesis

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17 Aug 2016
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Aldehydes and ketones not readily replaced by another group : The acyl groups of carboxylic acids and carboxy. Acid derivatives are attached to weaker bases than are the acyl groups of aldehydes & ketones. The lower the pka, the stronger the acid and the weaker its conjugate base. The h of an aldehyde & alkyl group of a ketone are too basic to be replaced by another group. Carbonic acid two oh groups attached to a carbonyl carbon. 16. 2 the structures of carboxylic acids & carboxy. Esters, -cooh"s and amides have two resonance contributors. 16. 3 the physical properties of carbonyl compounds. Amide > carboxylic acid > nitrile >> ester ~ acyl chloride ~ ketone ~ aldehyde. Similarity in ester, etc. b/c only the alcohol molecules can form h- bonds w/ each other. The bp of the other 4 carbonyls are higher b/c of the dipole-dipole interactions b/w the polar groups.

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