BIOD29H3 Lecture Notes - Bacteriophage, Bioterrorism
7 Apr 2014
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Blatimore effectively focuses on the genome, how do you take the genome and express it ssrna genome positive sense genome is already ready to be translated into proteins (nothing the cell or viral proteins need to do); when it has to replicate the genome to make new virions, it does need an rna thing that can copy rna do need rna dependent rna polymerase but just not at the first step ssrna genome negative, antisense has the genome that is complimentary to rna; need to first synthesize complimentary rna strand, mrna virus needs to bring in rna polymerase dsrna genome have both positive and antisense would expect to denature them and then use one strand (unfavorable) have to bring an rna dependent rna polymerase that breaks the dsrna, the copies the negative strand and make tons of mrna and is then used to make proteins.
