BIOC39H3 Lecture Notes - Lecture 11: Memory T Cell, Transplant Rejection, Blood Transfusion
9 Jun 2016
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Autograft= transplantation of tissue from one site to another on the same person. Syngenic transplant(isograft): a transplant between genetically identical indivduals, so twins. Allogenic transplant(allograft): a transplant between two genetically different individuals. Transplant is going to be recognized as non self. The type of alloreaction in transplantation depends on the type of tissue transplants. Transplant rejection: recipient derived antibodies and effector t cells attack the transplant. Graft-versus-host disease: donor derived mature and memory t cells attack patients tissues. Blood transfusion is the most common transplant in clinical medicine. Could the donated blood reject or attack the blood or tissues of the blood recipient: yes. Hyper acute rejection is caused by pre-existing antibodies binding to the graft. Abo antigens expressed on endothelial cells: pre-existing antibodies bind blood antigens and fix complement throughout graft vasculature. Hla class i also expressed on endothelium- can also cause hyperacture rejection: cross match test-blood serum from recipient is assessed for the presence of antibodies that.
